International product information

The product details shown after you switch describe the versions of Rho authorized outside the United States, including the Rho Score, which is not part of the US version.

US product information

The product details shown after you switch describe the version of Rho authorized in the United States, which reports whether a patient is Rho Positive.

Request a demo →
← All news
Research

JACR publishes Rho's performance in three independent datasets

Toronto. The Journal of the American College of Radiology published 16 Bit's validation of Rho, with areas under the curve of 0.89, 0.87 and 0.82 for low bone mineral density in three independent test sets totalling 6,100 patients.

The paper, prepared with research partners at the Canadian Multicentre Osteoporosis Study (CaMos), describes how Rho was trained on 62,023 X-ray and DXA pairs from community imaging centers and tested on three datasets it had never seen: patients from community imaging centers (n = 3,729), CaMos participants (n = 1,780) and the Osteoarthritis Initiative (n = 591).

Rho takes a frontal X-ray of the lumbar spine, thoracic spine, chest, pelvis, hand or knee, plus age and sex, and outputs the likelihood of low bone mineral density. Against DXA, the areas under the receiver operating characteristic curve for low bone mineral density were 0.89 (0.87 to 0.90), 0.87 (0.85 to 0.88) and 0.82 (0.79 to 0.85). Subset analyses showed similar results by sex, body part and race.

The journal printed the article in its April 2024 issue with an accompanying commentary.