International product information

The product details shown after you switch describe the versions of Rho authorized outside the United States, including the Rho Score, which is not part of the US version.

US product information

The product details shown after you switch describe the version of Rho authorized in the United States, which reports whether a patient is Rho Positive.

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About 16 Bit

We make existing imaging do more.

At 16 Bit, our vision is to harness the hidden potential of every medical image. We create medical AI software that reveals hidden information in existing medical imaging to enable smarter care. Our flagship product, Rho, transforms routine imaging into actionable insights, so patients who may have low bone density can be assessed before a fracture.

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For demos, clinical questions, or partnerships, use the contact form.

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Who we are

Radiologist founded and led.

Medical images are taken to answer a specific question, but they also contain a wealth of additional information. 16 Bit was founded by radiologists to find that information and put it in front of the clinicians who can act on it, so care can start earlier, using imaging patients have already had.

We build medical AI the way medicine expects it to be built: grounded in clinical evidence, validated independently, made under a certified quality system, and designed to fit the way care is delivered.

Mark Cicero and Alexander Bilbily standing behind the 16 Bit exhibit table, in front of a Rho banner
Co-founders and Co-CEOs Dr. Mark Cicero (left) and Dr. Alexander Bilbily, both fellowship-trained radiologists, trained at the University of Toronto during the deep learning renaissance in artificial intelligence.
Where we started

Made in Toronto.

16 Bit began in 2016, when Alexander Bilbily and Mark Cicero, then radiology residents, won a fellowship at the University of Toronto's Health Innovation Hub (H2i).

How 16 Bit started →
Milestones

From validation to routine care.

  1. 2022

    Health Canada license

    Rho is licensed in Canada and broadly deployed in routine care, after FDA Breakthrough Device designation in 2021.

  2. 2023

    US patent granted

    A US patent is granted for the Rho technology.

  3. 2024

    FDA De Novo authorization

    Rho is authorized for clinical use in the United States.

  4. 2026

    500,000+ X-⁠rays screened

    Rho passes half a million X-⁠rays screened in clinical care, early in 2026.

  5. 2026

    CE Mark and Taiwan FDA

    Rho is authorized in Europe and Taiwan, alongside Australia and Singapore.

Programs

Backed by Canada's health innovation programs.

Three Canadian programs have helped take Rho from validation to routine care. They funded development and studies, and connected us with hospitals ready to evaluate new technology.

  • CAN Health Network

    A national network that connects Canadian health technology companies with hospitals and health authorities to validate and buy their products.

    16 Bit is a member. A CAN Health commercialization project brought Rho to Sunnybrook Health Sciences Centre in 2023 for a prospective study, published in the Canadian Association of Radiologists Journal in 2025. The network gave 16 Bit its 2023 Impact Award for the project.

  • OBIO

    A not-for-profit that helps Canadian health technology companies reach adoption. Its Early Adopter Health Network matches companies with health organizations that evaluate their products.

    16 Bit is a member. Through the Early Adopter Health Network and OBIO's Life Sciences Critical Technologies and Commercialization program, University Health Network evaluated Rho on routine X-⁠rays from 2024, with results reported in 2025.

  • INOVAIT

    The pan-Canadian network for image-guided therapy and artificial intelligence, led by Sunnybrook Research Institute and supported by the Government of Canada's Strategic Innovation Fund.

    INOVAIT's Pilot Fund supported Rho's regulatory work and first real-world data from 2021. Since 2023, its Focus Fund has supported our project with True North Imaging to bring Rho into routine care, including clinical validation, regulatory submissions and new reporting tools. It funded in part the Syme et al. study in Skeletal Radiology (2026).

Our team

The team behind Rho.

Six members of the 16 Bit team around a restaurant table at a team dinner

  • Trust

    We earn trust through integrity, reliability, and sound evidence.

  • Quality

    We hold ourselves to the highest standard in clinical data, product design, and user experience.

  • Innovation

    We lead through medical and technical excellence toward a better future for patients.

  • Elegance

    We use our deep healthcare knowledge to create simple and effective solutions.

Careers

Build medical AI that is in clinical use.

We are a small team of clinicians, engineers, scientists and regulatory specialists. Rho reads routine X-⁠rays in clinical care, so the work you do here reaches patients.

  • Hard problems that matter

    Find signs of disease in images taken for other reasons, and ship it as medical device software under a quality system certified to ISO 13485.

  • Work that reaches patients worldwide

    Rho is authorized in the US, Canada, Europe, Australia, Singapore and Taiwan, and screens X-⁠rays in routine care every day.

  • A collegial, cross-disciplinary team

    Radiologists, machine learning and software engineers, researchers, and quality and regulatory specialists work side by side. You hear the clinical reasoning and the engineering trade-offs firsthand.

  • AI in how we work, not only what we build

    We use AI tools every day, in code, research, writing and operations, and we expect everyone to keep finding better ways to work with them.

  • Remote work

    Work from where you do your best work. The team gets together for socials, conferences, and customer visits.

  • Benefits and ownership

    Group health benefits, and stock options so the team shares in what it builds.

Open positions

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See Rho in your PACS workflow.

Let us walk you through how Rho can add value to your practice.

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