Independent validation from the Ottawa Hospital: AUC 0.84 in 4,878 patients
Ottawa. Researchers at the University of Ottawa and the Ottawa Hospital Research Institute, with no funding from 16 Bit, validated Rho against DXA in 4,878 patients. The area under the curve was 0.840 for low bone density, with comparable performance in men and women and in rural and urban patients.
The retrospective study paired 9,925 frontal radiographs with DXA scans acquired within a year. Performance held across the six body parts Rho reads, from pelvis (AUC 0.89) to hand (0.79). The authors note that access to DXA is limited in rural communities and conclude that Rho could help prioritize patients for DXA where access is limited.
16 Bit provided the software and had no role in the analysis.