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Skeletal Radiology: reporting Rho findings nearly doubled initial DXA referrals

In a 13-month study at a large independent imaging facility, Rho analyzed 34,162 X-rays. After radiologists began reporting its findings, initial DXAs rose 1.8 times and surveillance DXAs 1.4 times, and Rho-prompted DXAs found low bone density in 87% of patients versus 69% for DXAs arranged through usual care.

Rho flagged 19,004 of the 34,162 X-rays (56%), and radiologists chose to include the finding in 7,726 reports (41%). The gain in diagnostic yield was largest in patients having their first-ever DXA (84% versus 60%) and in men aged 65 and older (83% versus 45%), a group that usual care rarely screens.

The authors are 16 Bit employees, which the paper discloses. It is one of the first studies to measure how an AI screen for low bone density on routine X-rays changes DXA ordering in everyday practice: the authors note that how radiologists interact with such a tool, and whether patient management is affected, had not been reported (Syme et al., Skeletal Radiology, 2026).